Monday, April 13, 2009

Lentiviruses

Lentiviruses, on the other hand, can be used to treat cells that aren’t dividing.
You’re probably already familiar with a famous lentivirus: HIV. Vectors for
gene therapy were developed directly from the HIV virus itself. Although the
gutted virus vectors contain only 5 percent of their original DNA, rendering
them harmless, lentiviruses have the potential to regain the deleted genes if
they come in contact with untamed HIV virus particles (that is, the ones that
infect people with AIDS). Lentiviruses are also a bit dicey because they tend
to put genes right in the middle of host genes, leading to loss-of-function
mutations

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